Innovative practice involves medical interventions that deviate from standard practice in significant ways. For many patients, innovative practice offers the best chance of successful treatment. Because little is known about most innovative treatments, clinicians who engage in innovative practice might consider including extra procedures, such as scans or blood draws, to gather information about the innovation. Such information-gathering interventions can yield valuable information for modifying the innovation to benefit future patients and for designing scientific studies of the innovation. However, existing (...) guidelines do not say when or whether it is appropriate to add potentially risky information-gathering interventions for these purposes. As a result, clinicians may assume that information-gathering interventions are ethically inappropriate and should not be used in innovative practice. This assumption can lead to seriously negative consequences, such as increasing the likelihood that harmful or ineffective innovations will be adopted and creating new barriers to the development of genuinely beneficial treatments. We argue that health care institutions need to promote the responsible use of information-gathering interventions as an adjunct to innovative practice, and that these interventions are not clinical research and should not be subject to research oversight. (shrink)

It is argued that there is a role for the representational conception of vision, and that this is compatible with the task-level account advocated by Pessoa et al. However, the role of representations must be understood independently of our conscious experience of vision.

Gathers the pre-Sand Country Almanac writings of Aldo Leopold, showing that he was not born an ecologist, but evolved over time through experimentation and thought.

The Search for the Legacy of the USPHS Syphilis Study at Tuskegee is a collection of essays from experts in a variety of fields seeking to redefine the legacy of the infamous Tuskegee Syphilis Study. The essayists place the legacy of the study within the evolution of racial and ethnic relations in the United States. Contributors include two leading historians on the study, two former United States Surgeons General, and other prominent scholars from a wide range of fields.

Heisenberg’s uncertainty principle is a milestone of twentieth-century physics. We sketch the history that led to the formulation of the principle, and we recall the objections of Grete Hermann and Niels Bohr. Then we explain that there are in fact two uncertainty principles. One was published by Heisenberg in the Zeitschrift für Physik of March 1927 and subsequently targeted by Bohr and Hermann. The other one was introduced by Earle Kennard in the same journal a couple of months later. While (...) Kennard’s principle remains untarnished, the principle of Heisenberg has recently been criticized in a way that is very different from the objections by Bohr and Hermann: there are reasons to believe that Heisenberg’s formula is not valid. Experimental results seem to support this claim. -/- . (shrink)

Earl Conee has argued that the metaphysics of personal identity is irrelevant to the morality of abortion. He claims that doing all the substantial work in abortion arguments are moral principles and they garner no support from rival metaphysics theories. Conee argues that not only can both immaterialist and materialist theories of the self posit our origins at fertilization, but positing such a beginning doesn’t even have any significant impact on the permissibility of abortion. We argue that this thesis (...) is wrong on both accounts. We do so, in part, by relying on a hylomorphic rather than a Cartesian conception of the soul. There are good reasons for believing such a soul theory can favor an earlier origin than the leading materialist accounts. We also show that the theological metaphysics of hylomorphism provide greater support for a pro-life position than the Cartesian position Conee discusses. However, we argue that even on a materialistic account of personal identity, metaphysics has substantial bearing upon the morality of early abortions. (shrink)

This paper is concerned with the application of science to a practical activity. The story begins in the late eighteenth century, a period of agricultural innovation, with various authors urging that definite chemical knowledge should replace rule of thumb in the application of fertilisers. In the work of Archibald Cochrane, ninth Earl of Dundonald, we find this exhortation beginning to give way to descriptions of actual chemical experiments, and interpretations of equilibria in the soil. But it is only with (...) Davy's Agricultural chemistry of 1813 that we get clear descriptions of soil analyses that could be undertaken by a farmer, accompanied with a certain amount of biochemical information on the growth of plants. Davy's recommendations were essentially conservative; he provided support for the best practices already being recommended by innovators. His book is interesting too, for the light it casts upon his more theoretical writings. (shrink)

How certain is Heisenberg’s uncertainty principle? Heisenberg’s uncertainty principle is at the heart of the orthodox or Copenhagen interpretation of quantum mechanics. We first sketch the history that led up to the formulation of the principle. Then we recall that there are in fact two uncertainty principles, both dating from 1927, one by Werner Heisenberg and one by Earle Kennard. Finally, we explain that recent work in physics gives reason to believe that the principle of Heisenberg is invalid, while that (...) of Kennard still stands. (shrink)

How do you tell what’s right from what’s wrong? Can you always? What’s the difference between deduction, induction, and abduction? What are the best techniques for making an argument logically sound? In this fascinating little book, the smallest on its subject ever produced, philosopher Earl Fontainelle explores the ancient art of discursive Logic and demonstrates some of the techniques that have long been used to triumph over the debates and deceptions that assail us every day. Filled with helpful examples (...) of good and bad reasoning, Logic is an invaluable introduction to a defining human characteristic. (shrink)

The prefrontal cortex has long been suspected to play an important role in cognitive control, in the ability to orchestrate thought and action in accordance with internal goals. Its neural basis, however, has remained a mystery. Here, we propose that cognitive control stems from the active maintenance of patterns of activity in the prefrontal cortex that represent goals and the means to achieve them. They provide bias signals to other brain structures whose net effect is to guide the flow of (...) activity along neural pathways that establish the proper mappings between inputs, internal states, and outputs needed to perform a given task. We review neurophysiological, neurobiological, neuroimaging, and computational studies that support this theory and discuss its implications as well as further issues to be addressed. (shrink)

Introduction: "I chose therefore my party & am a whigg": the First and Third Earls of Shaftesbury as political icons / Patrick Muller, Dresden -- Part I. The First Earl of Shaftesbury -- Whig wit: Andrew Marvell and the Earls of Shaftesbury / Nigel Smith, Princeton University -- Trade for peace: a complete account of the First Earl of Shaftesbury: interest in Carolina's Indian trade / Andrew Agha, University of South Carolina, Columbia -- John Locke and the reputation (...) of the First Earl of Shaftesbury / Mark Goldie, University of Cambridge -- Part II. The Third Earl of Shaftesbury in his time -- Shaftesbury, an early voice of the radical enlightenment / Jonathan Israel, Institute for Advanced Study, Princeton University -- Shaftesbury and Locke: a tale of three letters / Daniel Carey, National University of Ireland, Galway -- "An equal commonwealth": Lord Ashley and the republican project of the late 1690s / Patrick Muller, Dresden -- Party politics in characteristicks / Jacob Sider Jost, Dickinson College, Carlisle -- Psychological and political balances: the Third Earl of Shaftesbury's reading of James Harrington / Laurent Jaffro -- (Re)defining the commonwealth: Shaftesbury's concept of political freedom / Angela Taraborrelli, St. John's University of Rome -- Shaftesbury's non-secular cosmopolitanism / David Alvarez, DePauw University, Greencastle -- Taste, the people and the public according to the Third Earl of Shaftesbury / Lawrence E. Klein, University of Cambridge -- Part III. The Third Earl of Shaftesbury: afterlife -- Art, morality and choice: the Third Earl of Shaftesbury and John Molesworth / William Molesworth, Dublin -- "Moral painting, by way of dialogue": Shaftesbury in the cry / Rebecca Anne Barr, National University of Ireland, Galway -- "Virtue pointing to her rugged mountain": Shaftesbury in America / James Pratt, University of Toronto -- Radicalizing sympathy: William Godwin's reading of Shaftesbury / Roman A. Barton, Humboldt-Universitat, Berlin. (shrink)

Evidentialism holds that the justified attitudes are determined entirely by the person's evidence. This book is a collection of essays, mostly jointly authored, that support and apply evidentialism.

The past 30 years has seen a theoretical and clinical renaissance in psychoanalysis, as well as a flourishing of Christian engagement in the fields of psychology and anthropology. This volume of essays stages a new conversation between Christianity and psychoanalysis that opens up new ways of thinking about the rich mosaic of human experience.

Evidentialism is a view about the conditions under which a person is epistemically justified in having a particular doxastic attitude toward a proposition. Evidentialism holds that the justified attitudes are determined entirely by the person's evidence. This is the traditional view of justification. It is now widely opposed. The essays included in this volume develop and defend the tradition. Evidentialism has many assets. In addition to providing an intuitively plausible account of epistemic justification, it helps to resolve the problem of (...) the criterion, helps to disentangle epistemic and ethical evaluations, and illuminates the relationship between epistemic evaluations of beliefs and the evaluation of the methods used to form beliefs. These issues are all addressed in the essays presented here. External world skepticism poses the classic problem for an epistemological theory. The final essay in this volume argues that evidentialism is uniquely well qualified to make sense of skepticism and to respond to its challenge. Evidentialism is a version of epistemic internalism. Recent epistemology has included many attacks on internalism and has seen the development of numerous externalist theories. The essays included here respond to those attacks and raise objections to externalist theories, especially the principal rival, reliabilism. Internalism generally has been criticized for having unacceptable deontological implications, for failing to connect epistemic justification to truth, and for failing to provide an adequate account of what makes basic beliefs justified. Each of these charges is answered in these essays. The collection includes two previously unpublished essays and new afterwords to five of the reprinted essays; it will be the definitive resource on evidentialism for all epistemologists. (shrink)

Part of the appeal of the biological approach to personal identity is that it does not have to countenance spatially coincident entities. But if the termination thesis is correct and the organism ceases to exist at death, then it appears that the corpse is a dead body that earlier was a living body and distinct from but spatially coincident with the organism. If the organism is identified with the body, then the unwelcome spatial coincidence could perhaps be avoided. It is (...) argued that such an identification would be a mistake. A living organism has a different part/whole relationship and persistence conditions than the alleged body. A case will be made that the concept ‘human body’ is a conceptual mess, vague in an unprincipled manner, and that an eliminativist stance towards dead bodies is the appropriate response. CiteULike Connotea Del.icio.us What's this? (shrink)

The paper explores the promise of ethical codes as a means to control unethical behavior in business. After a review of arguments for ethical codes from outside the business system, the paper outlines the arguments for codes from inside the business system at the level of the industry, firm and individual executive.The paper then discusses the problems of code design — the dilemma between specific practices and general precepts — and offers a model for a thoroughgoing code. This is followed (...) by a discussion of the problems of promulgation and code enforcement. (shrink)

E j lemmon, B a o williams, Bas van fraassen, And ruth marcus have argued on behalf of the existence of moral dilemmas, I.E., Cases where an agent is subject to conflicting absolute moral obligations. The paper criticizes this support and contends that no moral dilemma is possible.

Although a number of articles have addressed ethical perceptions and behaviors, few studies have examined ethics across cultures. This research focuses on measuring the job satisfaction, customer orientation, ethics, and ethical training of automotive salespersons in the U.S. and Taiwan. The relationships of these variables to salesperson performance were also investigated. Ethics training was found to be negatively related to perceived levels of ethicalness and performance. High performance U.S. salespeople reported high ethical behavior, while the opposite was true in Taiwan. (...) Customer orientation in both countries was influenced by ethics training. Managers should evaluate current ethics training programs to insure correct ethical behavior is taught and rewarded. (shrink)

As a continuation of the work of the third author in [5], we make further observations on the features of Galois cohomology in the general model theoretic context. We make explicit the connection between forms of definable groups and first cohomology sets with coefficients in a suitable automorphism group. We then use a method of twisting cohomology (inspired by Serre’s algebraic twisting) to describe arbitrary fibres in cohomology sequences—yielding a useful “finiteness” result on cohomology sets. Applied to the special case (...) of differential fields and Kolchin’s constrained cohomology, we complete results from [3] by proving that the first constrained cohomology set of a differential algebraic group over a bounded, differentially large, field is countable. (shrink)

This work has been selected by scholars as being culturally important, and is part of the knowledge base of civilization as we know it. This work was reproduced from the original artifact, and remains as true to the original work as possible. Therefore, you will see the original copyright references, library stamps (as most of these works have been housed in our most important libraries around the world), and other notations in the work. This work is in the public domain (...) in the United States of America, and possibly other nations. Within the United States, you may freely copy and distribute this work, as no entity (individual or corporate) has a copyright on the body of the work.As a reproduction of a historical artifact, this work may contain missing or blurred pages, poor pictures, errant marks, etc. Scholars believe, and we concur, that this work is important enough to be preserved, reproduced, and made generally available to the public. We appreciate your support of the preservation process, and thank you for being an important part of keeping this knowledge alive and relevant. (shrink)

This is an introduction to metaphysics for students and non-philosophers. (Philosophers: it's supposed to be the kind of book you can give to your friends and family, when they ask what you do for a living.) Contents: personal identity, fatalism, time, God, why not nothing?, free will, constitution, universals, necessity and possibility, what is metaphysics? (There is a second edition, which adds chapters on meta-metaphysics and the metaphysics of ethics.).

The paper argues against Timothy Williamson's anti-luminosity argument. It also offers an argument against luminosity from the possibility of defeat of introspective justification.